AMES, Iowa — Izaiah Brockington scored 15 points and Tyrese Hunter added 14 as No. 23 Iowa State.
Brockington converted all eight of his free throw attempts and made three 3-pointers for the Cyclones (16-5).
DaJuan Gordon led Missouri (8-12) with 15 points. Amari Davis scored 11.
Iowa State shot 58.3% in the second half and forced 18 Missouri turnovers.
The Cyclones seized control with a 15-0 run in the second half, building a 49-34 advantage.
Brockington, Caleb Grill and Aljaz Kunc hit consecutive 3-pointers during the scoring spree, pulling Iowa State out of an early funk.
Missouri missed ten of its first 11 shots in the second half.